| Children |
| | 1. Agnes ISSACK, b. 1673, Plymtree, Devon, England [Father: natural] [Mother: natural] |
| | 2. Susanna ISAAC, b. Apr 1653, Plymtree, Devon, England [Father: natural] [Mother: natural] |
| | 3. Thomas ISAAC, b. 7 Oct 1651, Plymtree, Devonshire, England d. 9 Oct 1651, Plymtree, Devon, England (Age 0 years) [Father: natural] [Mother: natural] |
| | 4. John ISAAC, b. Nov 1661, Plymtree, Devon, England d. Oct 1676, Clyst Hydon, Devon, England (Age 14 years) [Father: natural] [Mother: natural] |
| | 5. Joane ISAAC, b. 20 Apr 1666, Clyst Hydon, Devonshire, England [Father: natural] [Mother: natural] |
| | 6. Mary ISAAC d. Sep 1676, Clyst Hydon, Devon, England [Father: natural] [Mother: natural] |
| | 7. Robert ISAAC [Father: natural] [Mother: natural] |
| | 8. William ISAAC d. Sep 1724, Clyst Hydon, Devon, England [Father: natural] [Mother: natural] |
|